Biophotoniques et dynamiques moleculaires ultra-rapides (BIODYN)

The BioDyn team (Bio-photonics and ultrafast molecular Dynamics) develops experimental tools for femtosecond spectroscopy in the field of physical chemistry, to investigate the photoreactivity of (bio)organic or metal-organic molecules in the condensed phase. Typical processes of interest are photoreactions enabling photo-electric or photo-mechanical energy conversions at the molecular scale. Such photoreactions have applications in material science (e.g. photovoltaic devices, molecular switches, or motors), but they are also at work in biological systems (photosynthesis, vision). Among photoreactions of interest are (i)  photoinduced charge transfer or (ii)  ultrafast photo-isomerization reactions. The investigation of ultrafast photoreactions with fs laser pulses reveals the interplay between (coherent) electronic or vibrational dynamics and environmental effects, and how this interplay controls the photoreactions yield.

Besides, in the 3rd research axis called “biophotonics,” we explore physical chemistry at the interface between nanoscience and living matter. More specifically, we investigate the environment-sensitive photoreactivity of organic compounds that may be exploited to probe local interactions in biomolecules. We also investigate ultrafast excitation energy transfer reactions in functional, synthetic nanoparticles behaving like efficient light-harvesting antennas.

Presentation of the BioDyn team in video
The team in Nov. 2022 at the GDR UP conference

Research Activities

Photoisomerization
Energy Conversion
Bio-photonics
Experimental Development

Recent updates

  • Welcome to our new master students, Ana Tender, Romeo Ramos-tanghe and Haiyun Yuan for their M2 internship.
  •  Simon Rincon-Celis has won the best poster prize of QM2024 at IPCMS!
  • Matthew Mgbukwu successfully defended his PhD in December 2024!

Position Open

  • For Internship, PhD positions, and Postdoc positions, contact Stefan Haacke and Jeremie Leonard.

Membres de l’équipe :

Chargée de Recherche, Optique Ultra-rapide et Nanophotonique (DON)alexie.boyer@ipcms.unistra.fr
Tél: /Bureau: 1049
Voir la page personnelle
Post-doctorant, Optique Ultra-rapide et Nanophotonique (DON)xingjie.fu@ipcms.unistra.fr
Tél: /Bureau: 1028
Professeur, Optique Ultra-rapide et Nanophotonique (DON)Stefan.Haacke@ipcms.unistra.fr
Tél: /Bureau: 2029
Voir la page personnelle
Doctorante, Optique Ultra-rapide et Nanophotonique (DON)krystyna.herasymenko@etu.unistra.fr
Tél: +33(0)3 88 10 72 73Bureau: 2052
Directeur de Recherche, Optique Ultra-rapide et Nanophotonique (DON)Jeremie.Leonard@ipcms.unistra.fr
Tél: +33(0)3 88 10 72 43Bureau: 2403
Voir la page personnelle
Doctorant, Optique Ultra-rapide et Nanophotonique (DON)thomas.meric@ipcms.unistra.fr
Tél: /Bureau: 2109
Doctorant, Optique Ultra-rapide et Nanophotonique (DON)matthew.mgbukwu@ipcms.unistra.fr
Tél: +33(0)3 88 10 72 73Bureau: 2052
Doctorant, Optique Ultra-rapide et Nanophotonique (DON)simon.rinconcelis@ipcms.unistra.fr
Tél: /Bureau: 2109
Doctorant, Optique Ultra-rapide et Nanophotonique (DON)ronan.viel@ipcms.unistra.fr
Tél: +33(0)3 88 10 72 73Bureau: 2052

Publications récentes :

[1]
K. Herasymenko, D. Walisinghe, M. Konno, L. Barneschi, I. de Waele, M. Sliwa, K. Inoue, M. Olivucci, S. Haacke, Archaerhodopsin 3 is an ideal template for the engineering of highly fluorescent optogenetic reporters, Chemical Science 16 (2025) 761–774. https://doi.org/10.1039/d4sc05120c.
[1]
N. Barbosa, O. Urquidi, J. Brazard, T.B.M. Adachi, In situ/In vivo Optical Microspectroscopy to Probe the Emergence of Morphology, Chimia 78 (2024) 50–58. https://doi.org/10.2533/chimia.2024.50.
[1]
B. Freis, C. Kiefer, M. de los A. Ramirez, S. Harlepp, D. Mertz, B. Pichon, C. Iacovita, S. Laurent, S. Bégin, Defects or no defects? Or how to design 20-25 nm spherical iron oxide nanoparticles to harness both magnetic hyperthermia and photothermia, Nanoscale 16 (2024) 20542–20555. https://doi.org/10.1039/d4nr01397b.
[1]
A.M. Gharbi, D.S. Biswas, O. Crégut, P. Maly, P. Didier, A. Klymchenko, J. Léonard, Exciton annihilation and diffusion length in disordered multichromophoric nanoparticles, Nanoscale 16 (2024) 11550–11563. https://doi.org/10.1039/d4nr00325j.
[1]
M. Herve, B. Marekha, S. Mazerat, T. Mallah, M. Cammarata, S.F. Matar, S. Haacke, J. Léonard, E. Collet, Detection of a Jahn-Teller mode as an ultrafast fingerprint of spin-transition-induced charge transfer in CoFe Prussian Blue Analogue, Materials Advances 5 (2024) 3357–3366. https://doi.org/10.1039/d3ma01072d.
[1]
K. Heyne, S. Haacke, R.J.D. Miller, Watching atomically resolved structural dynamics-Blinded by the light, Structure 32 (2024) 650–651. https://doi.org/10.1016/j.str.2024.05.008.
[1]
M. Kurucz, I. Nikolinakos, J. Soueiti, T. Baron, F. Grifoni, W. Naim, Y. Pellegrin, F. Sauvage, F. Odobel, S. Haacke, Transparent Near-IR Dye-Sensitized Solar Cells: Ultrafast Spectroscopy Reveals the Effects of Driving Force and Dye Aggregation, ChemPhotoChem (2024) e202300175. https://doi.org/10.1002/cptc.202300175.
[1]
C. Zahn, M. Pastore, J.L.P. Lustres, P.C. Gros, S. Haacke, K. Heyne, Femtosecond Infrared Spectroscopy Resolving the Multiplicity of High-Spin Crossover States in Transition Metal Iron Complexes., Journal of the American Chemical Society 146 (2024) 9347–9355. https://doi.org/10.1021/jacs.4c01637.
[1]
T. Baron, W. Naim, M. Kurucz, I. Nikolinakos, B. Andrin, Y. Pellegrin, D. Jacquemin, S. Haacke, F. Sauvage, F. Odobel, Transparent and colorless DSSCs featuring thienyl-pyrrolopyrrole cyanine sensitizers, Journal of Materials Chemistry A 11 (2023) 16767–16775. https://doi.org/10.1039/d3ta02043f.
[1]
A. Brion, J. Chaud, M. Klimezak, F. Bolze, L. Ohlmann, J. Léonard, S. Chassaing, B. Frisch, A. Kichler, B. Heurtault, A. Specht, Photoactivatable Liposomes for Blue to Deep Red Light-Activated Surface Drug Release: Application to Controlled Delivery of the Antitumoral Drug Melphalan., Bioconjugate Chemistry 34 (2023) 1304–1315. https://doi.org/10.1021/acs.bioconjchem.3c00197.
[1]
R.B. Doak, R.L. Shoeman, A. Gorel, T.R.M. Barends, B. Marekha, S. Haacke, S. Nizinski, I. Schlichting, Dynamic catcher for stabilization of high-viscosity extrusion jets, Journal of Applied Crystallography 56 (2023) 903–907. https://doi.org/10.1107/S1600576723003795.
[1]
A. Jouaiti, L. Ballerini, H.-L. Shen, R. Viel, F. Polo, N. Kyritsakas, S. Haacke, Y.-T. Huang, C.-W. Lu, C. Gourlaouen, H.-C. Su, M. Mauro, Binuclear Copper(I) Complexes for Near-Infrared Light-Emitting Electrochemical Cells., Angewandte Chemie-International Edition 62 (2023) e202305569–e202305569. https://doi.org/10.1002/anie.202305569.
[1]
A.R. Marri, B. Marekha, T. Penfold, S. Haacke, P.C. Gros, Towards panchromatic Fe(ii) NHC sensitizers via HOMO inversion, Inorganic Chemistry Frontiers 10 (2023) 118–126. https://doi.org/10.1039/D2QI01903E.
[1]
T. Baron, W. Naim, I. Nikolinakos, B. Andrin, Y. Pellegrin, D. Jacquemin, S. Haacke, F. Sauvage, F. Odobel, Transparent and Colorless Dye-Sensitized Solar Cells Based on Pyrrolopyrrole Cyanine Sensitizers, Angewandte Chemie-International Edition 61 (2022) e202207459. https://doi.org/10.1002/anie.202207459.
[1]
A. Brion, J. Chaud, J. Léonard, F. Bolze, S. Chassaing, B. Frisch, B. Heurtault, A. Kichler, A. Specht, Red Light-Responsive Upconverting Nanoparticles for Quantitative and Controlled Release of a Coumarin-Based Prodrug., Advanced Healthcare Materials (2022) e2201474. https://doi.org/10.1002/adhm.202201474.
[1]
C. Cebrían, M. Pastore, A. Monari, X. Assfeld, P.C. Gros, S. Haacke, Ultrafast Spectroscopy of Fe(II) Complexes Designed for Solar Energy Conversion: Current Status and Open Questions, ChemPhysChem 23 (2022) e202100659. https://doi.org/https://doi.org/10.1002/cphc.202100659.
[1]
G. Fanciullo, I. Conti, P. Didier, A. Klymchenko, J. Léonard, M. Garavelli, I. Rivalta, Modelling quenching mechanisms of disordered molecular systems in the presence of molecular aggregates, Physical Chemistry Chemical Physics 24 (2022) 1787–1794. https://doi.org/10.1039/d1cp04260b.
[1]
M. Filatov Gulak, M. Paolino, R. Pierron, A. Cappelli, G. Giorgi, J. Léonard, M. Huix-Rotllant, N. Ferre, X. Yang, D. Kaliakin, A. Blanco-Gonzalez, M. Olivucci, Towards the engineering of a photon-only two-stroke rotary molecular motor., Nature Communications 13 (2022) 6433. https://doi.org/10.1038/s41467-022-33695-x.
[1]
M. Filatov Gulak, M. Paolino, R. Pierron, A. Cappelli, G. Giorgi, J. Léonard, M. Huix-Rotllant, N. Ferre, X. Yang, D. Kaliakin, A. Blanco-Gonzalez, M. Olivucci, Author Correction: Towards the engineering of a photon-only two-stroke rotary molecular motor., Nature Communications 13 (2022) 7541–7541. https://doi.org/10.1038/s41467-022-35006-w.
[1]
K. Magra, A. Frances-Monerris, C. Cebrian, A. Monari, S. Haacke, P.C. Gros, Bidentate Pyridyl-NHC Ligands: Synthesis, Ground and Excited State Properties of Their Iron(II) Complexes and the Role of the fac/mer Isomerism, European Journal of Inorganic Chemistry 2022 (2022) e202100818. https://doi.org/10.1002/ejic.202100818.
[1]
M. Paolino, M. Saletti, A. Reale, M. Licciardi, P. Varvara, A. Marquette, J. Léonard, C. Bonechi, A. Donati, G. Giorgi, G. Giuliani, B. Carlotti, F. Ortica, L. Latterini, M. Gentile, E. Paccagnini, M. Olivucci, A. Cappelli, Design, Synthesis and Characterization of a New Visible Light-Sensitive Molecular Switch and its PEGylation Towards a Self-Assembling Molecule., Chemistry-a European Journal 28 (2022) e202201477. https://doi.org/10.1002/chem.202201477.
[1]
X. Yang, M. Manathunga, S. Gozem, J. Léonard, T. Andruniów, M. Olivucci, Quantum–classical simulations of rhodopsin reveal excited-state population splitting and its effects on quantum efficiency, Nature Chemistry 14 (2022) 441–449. https://doi.org/10.1038/s41557-022-00892-6.

Experimental Set-Ups and Developments

Bio-photonics

Ultrafast photoisomerization

ENERGY CONVERSION